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Categories: Peptides & Proteins / Proteins

Product name			FHIT, Recombinant, Human (Fragile Histidine Triad)
Catalog No			USB-F4149-50B
Supplier’s Catalog No			F4149-50B
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight

Storage			-20°C
Other names
Grade			Highly Purified
Purity			≥ 90% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified.
Form			Supplied as a liquid in 50mM Tris-Acetate, pH 7.5, 1mM EDTA, 20% glycerol.
Reactivity life			6 months
Note			For reserch purpose only
Purity			≥ 90% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified.
Description			Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues Alterations and deletions of the FHIT (Fragile Histidine Triad) gene are strongly linked to the genesis and establishment of human tumors of the lung, cervix, breast, colon, stomach, and pancreas. In normal cells, FHIT may act as a tumor suppressor. Recombinant FHIT shows a band at 43kD on SDS-PAGE commassie blue stained gel. Dimers and Aggregates: ≤ 1% as determined by coomassie blue SDS-PAGE gel analysis. Endotoxin: ≤ 0.1ng/ug (IEU/ug) of Human FHIT. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.