Msx2, Control Peptide (Hox8)
Catalog No : USB-M4692-75AP
348.29€
0.00€
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| Product name | Msx2, Control Peptide (Hox8) | ||
|---|---|---|---|
| Catalog No | USB-M4692-75AP | ||
| Supplier’s Catalog No | M4692-75AP | ||
| Supplier | US Biologicals | ||
| Source antigen | |||
| Reactivity | Recognizes Msx2. Species Crossreactivity: Human and rodent. | ||
| Cross reactivity | Human, Rodent, | ||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Highly Purified | ||
| Purity | Highly purified (HPLC, MS) | ||
| Form | Supplied as a lyophilized powder. No preservative added. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Highly purified (HPLC, MS) | ||
| Description | Msx2, also known as HOX-8, is a homeobox containing transcription factor which is a member of the MSH family of homeobox proteins. Homeobox genes (HOX genes), encode DNA binding proteins that recognize specific sequences and modulate transcriptional activity (1). Msx-2 is believed to play a role in regulating bone development, particularly in sutures of cranial bone (5). Msx-2 is also expressed in sites of skin appendage formation and it has been proposed that Msx-2 is involved in the growth of skin and skin appendages (6). Msx2 mRNA is found expressed at higher levels in immature tumors, including a yolk sac tumor, seminoma, and chroiocarcinoma, and also in various tumors of epithelial origin (2). Msx2 gene expression is frequently activated in carcinoma-derived cell lines. The gene is inactive in NIH3T3 cells but is transcriptionally activated after transformation by v-Ki-ras suggesting that the Msx2 may play a role in cell transformation (3). Msx2 defects are a cause of craniosynostosis type 2 (CRS2), a disease that is characterized by premature fusion of calvarial sutures that leads to abnormal skull shape (4). Applications: Suitable for use in ELISA and Antibody Blocking. Other applications not tested. Recommended Dilution: Antibody Blocking: 5-10ug control peptide per 1ug of IgG or 1ul of antiserum Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. | ||
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