Core Binding Factor alpha 3, Human, Control Peptide (CBFA3)
Catalog No : USB-C7900-74B
417.25€
0.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Product name | Core Binding Factor alpha 3, Human, Control Peptide (CBFA3) | ||
|---|---|---|---|
| Catalog No | USB-C7900-74B | ||
| Supplier’s Catalog No | C7900-74B | ||
| Supplier | US Biologicals | ||
| Source antigen | Human synthetic peptide | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | |||
| Storage | -20°C | ||
|---|---|---|---|
| Other names | |||
| Grade | Purified | ||
| Purity | Purified | ||
| Form | Supplied as a lyophilized powder from PBS, 0.05% sodium azide. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | Purified | ||
| Description | The gene noggin encodes a member of one of at least four distinct gene families encoding secreted polypeptides that bind tomembers of the transforming growth factor-beta superfamily, suchas BMP, and inhibit the function of these signaling proteinsby preventing their interaction with receptors on the cell surface. Other antagonists with related functions includeChordin, Follistatin, Sclerostin and members of the DAN family. These BMP antagonists are assumed to be diffusible and therefore potentially important in the establishment of BMP-activity gradients in vivo. Although structurally distinct, members of these gene familieshave in some cases similar ligand specificity and overlappingpatterns of expression, and in the case of Chordin and Nogginthese proteins apparently are capable of at least partial compensationfor each other. In addition to these multiple secreted BMP antagonists, there are other secreted proteins whose primaryfunction is to overcome this antagonism. Thus, thereis a highly complex system to regulate the bioavailability andconsequently the activities of BMPs in the extracellularspace. BMPs are important regulators of key events in the processes of bone formation during embryogenesis, postnatal growth, remodeling and regeneration of the skeleton. The BMPs function by binding to a receptor complex that is found on all normal cells and is composed of type-I and –II receptors. The primary unit of bone formation is osteoblast, the bone forming cell. These osteoblast cells respond to physical loading by transducing signals that alter gene expression patterns. Cbfa (core binding factor), the osteoblast specific transcription factor plays an important role in osteoblast differentiation and function. Cbfa 3/ Runx3/ AML 2 (2 spliced forms), A protein 409aa long each in mouse, rat and 415aa long in human (Chr. 1p36). As Cbfa 2 it also bind to the core site of number of enhancers and promoters, interacts with TLE1. Its DNA binding is increased by heterodimerization. It shows subcellular nuclear localization. Source: 14aa peptide from human CBFA3 Location: Mid-region Species Sequence Homology: Mouse, rat-92%. Applications: ELISA: Control peptide can be used to coat ELISA plates at 1ug/ml Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | ||
Product Details
© 2020 Imugex All Rights Reserved