Ash2L, Recombinant, Human, aa96-628 (Set1/Ash2 Histone Methyltransferase Complex Subunit Ash2 Isoform A, Absent Small, or Homeotic Discs 2-like)
Catalog No : USB-219438
509.21€
0.00€
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| Product name | Ash2L, Recombinant, Human, aa96-628 (Set1/Ash2 Histone Methyltransferase Complex Subunit Ash2 Isoform A, Absent Small, or Homeotic Discs 2-like) | ||
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| Catalog No | USB-219438 | ||
| Supplier’s Catalog No | 219438 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 60.1 | ||
| Storage | -70°C | ||
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| Other names | |||
| Grade | Purified | ||
| Purity | ~90% (SDS-PAGE) | ||
| Form | Supplied as a liquid in 50mM Tris, pH 8.0, 150mM sodium chloride, 20% glycerol. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~90% (SDS-PAGE) | ||
| Description | ASH2L is the human homolog of the Drosophila absent, small or homeotic discs 2 (ash2) gene product, a member of the trithorax group (TrxG) of proteins.The TrxG gene products in Drosophila and their mammalian homologs are responsible for controlling gene transcription. The ASH2L protein is a component of various multisubunit protein complexes, including the large complex of proteins associated with the SET1 (MLL) family of lysine methyltransferases. ASH2L, along with WDR5 and RbBP5, form the human MLL1 core protein complex. MLL1-5 protein complexes catalyze the di- and trimethylation of histone H3 at lysine 4 (H3K4me2/me3), leading to the maintenance of global H3K4 trimethylation. Post-translational modifications of ASH2L have also been described showing methylation of Arg-296 by protein-arginine methyltransferease 1 (PRMT1) in vitro and in cells and by PRMT5 in vitro. Further experimental evidence in rats suggests that ASH2L cooperates with Ha-RAS to transform rat embryonic fibroblasts, implicating ASH2L as a novel oncoprotein. Source: Recombinant protein corresponding to aa96-628 from human Ash2L, expressed in E. coli. Molecular Weight: ~60.1kD (aa96-628) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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