CREB Binding Protein, Recombinant, Human, aa1081-1197, GST-tag (cAMP-responsive Element-binding Protein 1 CREB-1, CBP, CREBBP)
Catalog No : USB-219668
457.48€
0.00€
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| Product name | CREB Binding Protein, Recombinant, Human, aa1081-1197, GST-tag (cAMP-responsive Element-binding Protein 1 CREB-1, CBP, CREBBP) | ||
|---|---|---|---|
| Catalog No | USB-219668 | ||
| Supplier’s Catalog No | 219668 | ||
| Supplier | US Biologicals | ||
| Source antigen | Recombinant, E. coli | ||
| Reactivity | |||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 40.8 | ||
| Storage | -70°C | ||
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| Other names | |||
| Grade | Highly Purified | ||
| Purity | ~95% (SDS-PAGE) | ||
| Form | Supplied as a liquid in 50mM Tris, pH 7.5, 500mM sodium chloride, 5mM b-mercaptoethanol, 5% glycerol. | ||
| Reactivity life | 12 months | ||
| Note | For reserch purpose only | ||
| Purity | ~95% (SDS-PAGE) | ||
| Description | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The cAMP response element-binding protein (CREB) binding protein (CREBBP) bromodomain has been shown to modulate the stability and function of the tumor suppressor protein p53. CREBBP bromodomain recognizes the acetylated lysine residue 382 on p53. This product contains the bromodomain region of CREBBP. Source: Recombinant protein corresponding to aa1081-1197 from the bromodomain region of human CREB Binding Protein, fused to GST-tag at N-terminal, expressed in E. coli. Molecular Weight: ~40.8kD (aa1081-1197 + NT GST Tag) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | ||
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