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Categories: Peptides & Proteins / Proteins

Product name			EYA2, Recombinant, Human, aa244-514, His-Tag (Eyes absent homolog 2, EAB1)
Catalog No			USB-351217
Supplier’s Catalog No			351217
Supplier			US Biologicals
Source antigen			Recombinant, human from E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			33.2

Storage			-20°C/-70°C
Other names
Grade			Purified
Purity			~90% (SDS-PAGE)
Form			Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 0.15M sodium chloride, 1mM DTT, 40% glycerol.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~90% (SDS-PAGE)
Description			EYA2, also known as eyes absent homolog 2, is a member of tyrosine phosphatase family that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). This protein promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Source: Recombinant protein corresponding to aa244-514 from human EYA2, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~33.2kD (295aa) AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMERVFVW DLDETIIIFH SLLTGTFASR YGKDTTTSVR IGLMMEEMIF NLADTHLFFN DLEDCDQIHV DDVSSDDNGQ DLSTYNFSAD GFHSSAPAAN LCLGSGVHGG VDWMRKLAFR YRRVKEMYNT YKNNVGGLIG TPKRETWLQL RAELEALTDL WLTHSLKALN LINSRPNCVN VLVTTTQLIP ALAKVLLYGL GSVFPIENIY SATKTGKESC FERIMQRFGR KAVYVVIGDG VEEEQGAKKH NMPFWRISCH ADLEALRHAL ELEYL Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.