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Categories: Peptides & Proteins / Proteins

Product name			HES2, Recombinant, Human, aa1-173, His-Tag (Transcription factor HES-2, Hairy and enhancer of split 2)
Catalog No			USB-351283
Supplier’s Catalog No			351283
Supplier			US Biologicals
Source antigen			Recombinant, human from E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			20.9

Storage			-20°C/-70°C
Other names
Grade			Purified
Purity			~80% (SDS-PAGE)
Form			Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 0.4M urea, 10% glycerol.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~80% (SDS-PAGE)
Description			Hairy and enhancer of split 2, also known as HES2, is a member of the HES family and contains one basic helix-loop-helix (bHLH) domain and one orange domain. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. Activation of Notch signaling pathway leads to activation of HES family genes through the interaction between Notch intracellular domain and RBPSUH (CSL). HES2 is expressed in a variety of adult and embryonic tissue. Source: Recombinant protein corresponding to aa1-173 from human HES2, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~20.9kD (196aa) AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMGLPRRA GDAAELRKSL KPLLEKRRRA RINQSLSQLK GLILPLLGRE NSNCSKLEKA DVLEMTVRFL QELPASSWPT AAPLPCDSYR EGYSACVARL ARVLPACRVL EPAVSARLLE HLWRRAASAT LDGGRAGDSS GPSAPAPAPA SAPEPASAPV PSPPSPPCGP GLWRPW Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.