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Categories: Peptides & Proteins / Proteins

Product name			STAT3, Control Peptide (Signal Transducer and Activator of Transcription 3, Acute-phase Response Factor, APRF)
Catalog No			USB-S7971-25
Supplier’s Catalog No			S7971-25
Supplier			US Biologicals
Source antigen			Synthetic peptide
Reactivity
Cross reactivity
Applications
Molecular weight			1711

Storage			-20°C
Other names
Grade			Highly Purified
Purity
Form
Reactivity life			12 months
Note			For reserch purpose only
Purity
Description			Control peptide for the STAT 3 rabbit polyclonal antibody, S7971-20. Stat3 is a key signaling molecule for many cytokines and growth-factor receptors (1), and is required for murine fetal development (2). Additionally, Stat3 is constitutively activated in a number of human tumors (3,4) and possesses oncogenic potential (5) and anti-apoptotic activities (3). Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding (6,7). Transcriptional activation seems to be regulated by phosphorylation at Ser727 via the MAPK or mTOR pathway (8,9). Stat3 isoform expression appears to reflect biological function: the relative expression levels of Stat3a (86 kD) and Stat3b (79kD) depend on cell type, ligand exposure or maturation stage of the cells (10). It is notable that Stat3b lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain (8). Sequence (linear): H2N-Ser-Leu-Met-Gln-Asn-Asn-Gly-Glu-Gly-Ala-Glu-Pro-Ser-Ala-Cys-NH2 Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.