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Categories: Peptides & Proteins / Proteins

Product name			Tudor Domain Containing Protein 4, Recombinant, Human, His-Tag, aa30-139 (TDRD4)
Catalog No			USB-220360
Supplier’s Catalog No			220360
Supplier			US Biologicals
Source antigen			Recombinant, E. coli
Reactivity
Cross reactivity
Applications
Molecular weight			14.6

Storage			-70°C
Other names
Grade
Purity			~98% (SDS-PAGE)
Form			Supplied as a liquid in 25mM Tris, pH 8.0, 20% glycerol.
Reactivity life			12 months
Note			For reserch purpose only
Purity			~98% (SDS-PAGE)
Description			Tudor domains are small protein structural motifs of about ~50aa related to the “royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification, and chromatin remodeling. The Tudor domains recognize symmetric methylated arginine or methylated lysine residues. Tudor domain proteins act as an oncogene and play a very important role in HCC and colon cancer. TDRD is also involved in RISC complex and interacts with AEG-1 oncogene. The Tudor domain can bind to methylated arginine protein and promote tumor angiogenesis in human hepatocellular carcinoma, etc. TDRD4 is a candidate CT antigen expressed in a subset of liver cancers. Source: Recombinant protein corresponding to aa30-139 from human TDRD4, fused to His-tag at N-terminal, expressed in E. coli. Molecular Weight: ~14.6kD (110aa + NT 6x His-tag) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.